Role of platelets for the function of keratinocytes in dermatitis

我们已报道，血小板在变态反应性皮炎的发病机制中起重要作用。表皮角质形成细胞通过表达黏附分子和释放细胞因子，深入参与过敏性皮炎的发病机制。然而，在皮炎中，血小板在角质形成细胞功能中的作用尚不清楚。我们对血小板对角质形成细胞功能的影响进行了实验研究。我们的研究结果提示，血小板可能影响角质形成细胞的功能，然而，我们还没有提供足够的数据来阐明血小板对角质形成细胞功能的作用。

We have reported that platelets play important roles in pathomechanisms of allergic dermatitis. Keratinocytes in the epidermis are deeply involved in pathomechanisms of allergic dermatitis by expressing adhesion molecules and releasing cytokines. However, the role of platelets for the function of keratinocytes in dermatitis has yet to be clarified. We performed the experiments about the role of platelets on keratinocyte function. The results of our study suggest that platelets may affect the function of keratinocytes, however, we have not shown enough data to clarify the role of platelets on keratinocyte function.