Does maternal administration of antipsychotics have a prophylactic effect on the development of psychotic features in offspring?: An animal study using the asphyxia model of schizophrenia.

大鼠在剖宫产期间宫内缺氧15min建立的精神分裂症窒息模型，6周龄时海马齿状回颗粒细胞减少，12周龄时出现多巴胺能失调，两者均被认为是精神分裂症样表型。使用这个模型，我们在这项研究中检查了母亲服用抗精神病药物是否可以防止她们的后代出现精神分裂症样特征。怀孕的雌性大鼠每天服用氯氮平(0。5或5.0 mg/kg)，氟哌啶醇(0。1 mg/kg或1.0 mg/kg)，或生理盐水灌胃。他们的幼崽在有或没有窒息的情况下进行了剖腹产。出生12周后，幼鼠接受冰毒(0。5 mg/kg、2.0 mg/kg)或生理盐水灌胃，测定小鼠的运动能力。结果，氯氮平或氟哌啶醇对甲基苯丙胺诱导的这些学生的运动活动都没有明显的影响。这些结果不支持母亲服用抗精神病药物可能对其后代的精神病特征的发展具有预防作用的假设。

The asphyxia model of schizophrenia, in which rat pups were exposed to 15 min of intrauterine anoxia during Cesarean section birth, showed a reduction in hippocampal dentate granule cells at 6 weeks of age and dopaminergic dysregulation at 12 weeks after birth, both have been regarded as schizophrenia-like phenotypes. Using this model, we examined in this study whether administration of antipsychotics to mothers prevent the development of schizophrenia-like features in their offspring. Pregnant female rats were administered daily either with clozapine(0. 5 or 5. 0 mg/kg), haloperidol(0. 1 or 1. 0 mg/kg), or saline by intraperitoneal infusions. Their pups were delivered Cesarean section with or without asphyxia. Twelve weeks after birth, pups were challenged with methamphetamine(0. 5 or 2. 0 mg/kg) or saline, and their locomotor activity were measured. As a result, there were no significant effects of either dose of clozapine or haloperidol on methamphetamine-induced locomotor activity in those pups.These results failed to support the hypothesis that maternal administrations of antipsychotic might have a prophylactic effect on the development of psychotic features in their offspring.