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Investigation to elucidate the mechanism of the onset of acute lung injury by the EGFR inhibitors, and the development of that suppression method

Investigation to elucidate the mechanism of the onset of acute lung injury by the EGFR inhibitors, and the development of that suppression method
EGFR抑制剂引起急性肺损伤发病机制的研究及其抑制方法的开发
批准号:
22791619
负责人:
ISHIGURO Yukari
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
翻译
急性间质性肺炎是表皮生长因子受体(EGFR)-酪氨酸激酶抑制剂(TKI)的严重副作用之一,尽管其原因尚不清楚。在本研究中,我们研究了用EGFR阻滞剂处理的癌细胞诱导人肺成纤维细胞纤维化。这些数据提示急性间质性肺炎是由EGFR阻滞剂治疗的癌细胞诱导的一些未知因素。
英文摘要
Acute interstitial pneumonia is one of serious side effects of epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitor(TKI), although that cause is still unknown. In the present study, we investigated that cancer cells treated with EGFR blocker induce fibrosis of human lung fibroblast. These data suggested that acute interstitial pneumonia was induced some unknown factors from cancer cells treated with EGFR blocker.
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会议论文
Examination of the optimal condition on the in vitro sensitivity to telomelysin in head and neck cancer cell lines.
头颈癌细胞系对端粒溶素体外敏感性的最佳条件的检查。
DOI: --
发表时间: 2011
期刊: Auris Nasus Larynx
影响因子: 1.7
作者: [Sakakibara A, Tsukuda M, Kondo N, Ishiguro Y, Kimura M, Fujita K, Takahashi H, Matsuda H]
通讯作者: Matsuda H
DOI: 10.3892/or_00000720
发表时间: 2010-04-01
期刊: ONCOLOGY REPORTS
影响因子: 4.2
作者: [Kondo, Norio, Tsukuda, Mamoru, Matsuda, Hideki]
通讯作者: Matsuda, Hideki
Investigation to determine the cause of interstitial pneumonia by the EGFR inhibitors, and the development of that suppression method
  • 批准号:
    20791210
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.75万
  • 财政年份:
    2008
  • 负责人:
    ISHIGURO Yukari
  • 依托单位:
海外基金