Difference of cell cycle between nifedipine responders and non-responders

为了阐明硝苯地平诱导牙龈过度生长的原因，本研究探讨了硝苯地平治疗过程中，有无牙龈过度生长的牙周成纤维细胞在细胞周期时相分布和在脂多糖存在下的细胞凋亡方面的差异。与硝苯地平非反应性细胞相比，硝苯地平反应性细胞的细胞周期进程加快，细胞凋亡减少，凋亡调节蛋白Bax、细胞色素c、Caspase-3和-9的表达减少。

In this study, to elucidate the cause of nifedipine-induced gingival overgrowth, it has been evaluated whether there is differences in the cell cycle phase distribution and the apoptosis in the presence of lipopolysaccharide between gingival fibroblasts derived from patients with/without gingival overgrowth during nifedipine-treatment. Nifedipine reactive cells underwent the enhanced cell cycle progression, the diminished apoptosis, and the decreased expression of apoptosis regulatory proteins(Bax, Cytochrome c, Caspase-3 and-9) in comparison with nifedipine non-reactive cells.