Difference of cell cycle between nifedipine responders and non-responders

硝苯地平应答者与无应答者细胞周期的差异

• 批准号: 22791815
• 负责人: TAKEUCHI Reiri
• 金额: $ 0.83万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791815/
• 关键词: 薬物性歯肉増殖症; ニフェジピン; 歯肉線維芽細胞; 細胞周期; アポトーシス; リポ多糖; ミトコンドリア

In this study, to elucidate the cause of nifedipine-induced gingival overgrowth, it has been evaluated whether there is differences in the cell cycle phase distribution and the apoptosis in the presence of lipopolysaccharide between gingival fibroblasts derived from patients with/without gingival overgrowth during nifedipine-treatment. Nifedipine reactive cells underwent the enhanced cell cycle progression, the diminished apoptosis, and the decreased expression of apoptosis regulatory proteins(Bax, Cytochrome c, Caspase-3 and-9) in comparison with nifedipine non-reactive cells.

为了阐明硝苯地平诱导牙龈过度生长的原因，本研究探讨了硝苯地平治疗过程中，有无牙龈过度生长的牙周成纤维细胞在细胞周期时相分布和在脂多糖存在下的细胞凋亡方面的差异。与硝苯地平非反应性细胞相比，硝苯地平反应性细胞的细胞周期进程加快，细胞凋亡减少，凋亡调节蛋白Bax、细胞色素c、Caspase-3和-9的表达减少。

项目成果

Reduction in lipopolysaccharide-induced apoptosis of fibroblasts obtained from a patient with gingival overgrowth during nifedipine-treatment

• DOI: 10.1016/j.archoralbio.2011.03.006
• 发表时间: 2011-10-01
• 期刊: ARCHIVES OF ORAL BIOLOGY
• 影响因子: 3
• 作者: Takeuchi, Reiri;Matsumoto, Hiroko;Fujii, Akira
• 通讯作者: Fujii, Akira

Effects of 18a- and 18b-glycyrrhetinic acid on apoptosis and proliferation by phenytoin and cyclosporin A in human gingival fibroblasts

18a-和18b-甘草次酸对苯妥英钠和环孢素A人牙龈成纤维细胞凋亡和增殖的影响

• 发表时间: 2011
• 期刊: 歯科薬物療法
• 作者: Reiri Takeuchi;Hiroko Matsumoto;Yoshiaki Akimoto;Akira Fujii
• 通讯作者: Akira Fujii

The Mechanism of Phenytoin-induced Gingival Overgrowth

苯妥英钠引起牙龈过度生长的机制

• 发表时间: 2012
• 作者: Reiri Takeuchi;Makiko Ono;Yoshiaki Akimoto;Akira Fujii; Hiroko Matsumoto;那須優則，中原 貴，井出吉昭，富永徳子，田巻友一，石川 博;佐々木秀憲他;Reiri Takeuchi，Hiroko Matsumoto， Yoshiaki Akimoto，Akira Fujii
• 通讯作者: Reiri Takeuchi，Hiroko Matsumoto， Yoshiaki Akimoto，Akira Fujii

The Mechanism of Nifedipine- induced Gingival Overgrowth

硝苯地平致牙龈增生的机制

• 发表时间: 2011
• 作者: Takeuchi R;Matsumoto H;Akimoto Y;Fujii A
• 通讯作者: Fujii A

A possible role of cyclosporine A for gingival overgrowth

环孢菌素 A 对牙龈过度生长的可能作用

• 发表时间: 2010
• 作者: Reiri Takeuchi;Hiroko Matsumoto;Yoshiaki Akimoto;Akira Fujii
• 通讯作者: Akira Fujii