The establishment of diagnostic method for caries risk and the clinical application

龋病风险诊断方法的建立及临床应用

• 批准号: 22792071
• 负责人: OHTA Masumi
• 金额: $ 2.33万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792071/
• 关键词: 齲蝕感受性; SNPs解析; 生活習慣病; 遺伝子検査; 疾病予防

The objective of this study was to screen for single nucleotide polymorphisms(SNPs) in genes coding KCNJ12 and STIM1, in patients with severs caries and in low caries susceptibility individuals. We investigated whether SNPs in both KCNJ12 and STIM1 genes are associated with the caries susceptibility. Cases were 103 children ages 5-6 yrs. Statistical analysis based on Chi-square test revealed a significant association of the rs4985866 SNP of KCNJ12 with susceptibility to caries in low-S. mutans group. Within the limitations of this study, rs3813880 SNP and rs3750996 SNP of STIM1 seem to be negatively associated, while rs4985866 SNP of KCNJ12 is associated with caries susceptibility.

本研究的目的是筛选KCNJ 12和STIM 1基因的单核苷酸多态性（SNPs），在重度龋患者和低龋易感个体。我们研究了KCNJ 12和STIM 1基因的SNPs是否与龋病易感性相关。病例为103名5-6岁儿童。基于卡方检验的统计分析显示，KCNJ 12的rs 4985866 SNP与低S龋易感性显著相关。mutans组。在本研究的范围内，STIM 1的rs3813880 SNP和rs3750996 SNP似乎与龋病易感性呈负相关，而KCNJ 12的rs 4985866 SNP与龋病易感性相关。