Development of New Acylation Reactions via Aromatic Carbon-Hydrogen Bond Cleavaege by Transition Metal Catalysts

近年来，过渡金属络合物通过裂解未反应的碳氢键来实现催化功能化得到了广泛的研究。作为这类反应中的一种新方法，我们发展了一种利用酰氯催化引入酰基的反应。芳基吡啶与苯甲酰氯、烯酰氯等酰氯反应，进行邻位选择性酰化反应，得到二苯甲酮和烯酮类化合物。

Catalytic functionalization via cleavage of unreactive carbon-hydrogen bonds by transition metal complexes has been widely studied in recent years. As a new method in this class of reactions, we developed a reaction for catalytic introduction of acyl groups using acyl chlorides. When arylpyridines are reacted with acyl chlorides such as benzoyl chlorides and alkenoyl chlorides, ortho-selective acylation proceeded to give benzophenone and enone derivatives.