Development of New Acylation Reactions via Aromatic Carbon-Hydrogen Bond Cleavaege by Transition Metal Catalysts

近年来，过渡金属配合物裂解非反应性碳氢键的催化功能化得到了广泛的研究。作为这类反应的新方法，我们开发了一种用酰基氯化物催化引入酰基的反应。当芳基吡啶与酰基氯化物如苯甲酰氯化物和烯酰氯化物反应时，邻选择性酰化反应产生二苯甲酮和烯酮衍生物。

Catalytic functionalization via cleavage of unreactive carbon-hydrogen bonds by transition metal complexes has been widely studied in recent years. As a new method in this class of reactions, we developed a reaction for catalytic introduction of acyl groups using acyl chlorides. When arylpyridines are reacted with acyl chlorides such as benzoyl chlorides and alkenoyl chlorides, ortho-selective acylation proceeded to give benzophenone and enone derivatives.