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Design of Metalloproteins based on principal of inter-element chemistry

Design of Metalloproteins based on principal of inter-element chemistry
基于元素间化学原理的金属蛋白设计
批准号:
22750156
负责人:
MATSUO Takashi
金额:
$2.25万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
Some artificial metalloproteins were successfully constructed from the aspects of "fashions of metal coordination","inter-element principal(interactions between elements)" and "structural characteristics of proteins". An organometallic artificial protein with a C-coordinated metal center was prepared through inhibition mechanism of serine proteases. Furthermore, we successfully develop a protein structure-based switching system of emission property of a metal complex attached onto the surface the protein. We also found autoreduction of a copper ion with S-coordination, which was constructed at the active site of a chemically modified subtilisin.
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Creation of Artificial Organometallic Enzyme by Using Intrinsic Mechanism of Parent Protein
利用母体蛋白的内在机制创建人工有机金属酶
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Takashi Matsuo, Chie Imai, Takefumi Yoshida, Akira Fujii, Takashi Saito, Takashi Hayashi, Shun Hirota]
通讯作者: Shun Hirota
プロテアーゼの機能メカニズムに基づく有機金属錯体含有タンパク質の創成
基于蛋白酶的功能机制创建含有机金属复合物的蛋白质
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [吉田武史, 松尾貴史, 今井千絵, 廣田俊]
通讯作者: 廣田俊
DOI: 10.1039/c1ob05552f
发表时间: 2011-06
期刊: Organic & biomolecular chemistry
影响因子: 3.2
作者: [Zhonghua Wang;T. Matsuo;S. Nagao;S. Hirota]
通讯作者: Zhonghua Wang;T. Matsuo;S. Nagao;S. Hirota
サブチリシン活性部位の化学修飾に基づくシステイン配位銅錯体の構築
基于枯草杆菌蛋白酶活性位点化学修饰的半胱氨酸配位铜配合物的构建
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [権田勝也, 松尾貴史, 廣田俊]
通讯作者: 廣田俊
12
    Development of a new approach to the treatments in conservative dentistry based on a concept for home or visit care.
    • 批准号:
      17K11708
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2017
    • 负责人:
      MATSUO Takashi
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    • 批准号:
      26462885
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
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    • 财政年份:
      2014
    • 负责人:
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    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
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      2012
    • 负责人:
      MATSUO Takashi
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    • 批准号:
      24550189
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.58万
    • 财政年份:
      2012
    • 负责人:
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    • 依托单位:
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