Elucidation of molecular mechanisms of ion-transporter proteins by using difference infrared spectroscopy

点击翻译按钮获取中文摘要

Ion-transporter proteins, ion channels, and receptors in cell membrane work for production of biological energy, generation of bioelectric signal, and reception of external stimuli, respectively. To investigate the molecular mechanisms of these membrane proteins, we applied several methods of difference infrared spectroscopy on them, which provide structural information of biomolecules in action. The molecular mechanisms of microbial rhodopsins, V-type ATPase, and a potassium ion channel, KcsA, were partly elucidated based on the structural changes detected by our methods.