Molecular mechanism of male-type differentiation in mouse germ cells
Molecular mechanism of male-type differentiation in mouse germ cells
批准号:
22770169
负责人:
SUZUKI Atsushi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
In our present study, we identify CNOT1, a component of the CCR4-NOT deadenylation complex, as a direct factor mediating the interaction with NANOS2. We find that the first 10 amino acids(AAs) of NANOS2 are required for this binding. We further observe that a NANOS2 mutant lacking these first 10 AAs(NANOS2-ΔN10) fails to rescue defects in the Nanos2-null mouse. Our current data thus indicate that the interaction with the CCR4-NOT deadenylation complex is essential for NANOS2 function.
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哺乳類生殖細胞形成機構の解析-生殖医療への応用に向けて
哺乳动物生殖细胞形成机制分析-面向生殖医学应用
DOI:
--
发表时间:
2011
期刊:
医学のあゆみ
影响因子:
--
作者:
[鈴木敦, 栗原靖之, 相賀裕美子]
通讯作者:
相賀裕美子
生殖細胞雄性分化におけるRNP複合体の解析
RNP复合物在生殖细胞雄性分化中的分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[鈴木敦, 栗原靖之, 相賀裕美子, 鈴木敦]
通讯作者:
鈴木敦
Interaction between NANOS2 and CCR4-NOT deadenylation complex is essential for male germ cell development in mouse
NANOS2 和 CCR4-NOT 去腺苷酸化复合物之间的相互作用对于小鼠雄性生殖细胞发育至关重要
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Suzuki A, Igarashi K, Aisaki K, Kanno J, Saga Y.]
通讯作者:
Saga Y.
Functional difference between NANOS2 and NANOS3 in the interaction with the CCR4-NOT deadenylation complex
NANOS2 和 NANOS3 在与 CCR4-NOT 脱腺苷酸化复合物相互作用方面的功能差异
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Morita Y., Saga Y., Suzuki A.]
通讯作者:
Suzuki A.
The essential role of NANOS2 zinc finger motif in the assembly of P-bodies
NANOS2锌指基序在P体组装中的重要作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nakajima Y., Saga Y., Suzuki A.]
通讯作者:
Suzuki A.
共 7 条
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