Regulation of stress granule formation by oxidative stress

应激颗粒（Stress granules，SGs）是一种存在于环境应激（如应激）后的真核细胞胞质中的相致密颗粒。G.亚砷酸盐、缺氧）。SGs在细胞存活中起重要作用。在这项研究中，考虑到SG作为多功能结构，我们寻找新的SG相关蛋白，并确定了USP 10。此外，USP 10被证明对于维持SG的稳定性是重要的。接下来，通过观察多重胁迫条件下SGs的形成，我们发现SGs的形成在氧化胁迫下受到强烈抑制。

Stress granules(SGs) are phase-dense particles that appear in the cytoplasm of eukaryotic cells that have been exposed to environmental stress(e. g. arsenite, hypoxia). SGs play important role in cell survival. In this study, considering SGs as multifunctional structures, we searched for novel SG-associated proteins and identified USP10. Moreover, USP10 turned out to be important for maintaining the stability of SGs. Next, by observing SGs formation under multiple stress conditions, we found that formation of SGs was strongly inhibited under oxidative stress.