Molecular mechanisms of adaptive evolution in primate taste receptors

灵长类味觉受体适应性进化的分子机制

• 批准号: 22770233
• 负责人: SUGAWARA Toru
• 金额: $ 2.66万
• 依托单位: National Research Institute for Child Health and Development
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22770233/
• 关键词: 遺伝子; 進化; ゲノム; チンパンジー; ニホンザル; 霊長類; 苦味受容体; 幹細胞; 多型; 感覚受容体

Bitter taste is mediated by T2R genes, which belong to the G protein-coupled receptors. We investigated the intraspecies variations of functional T2R genes in chimpanzees and Japanese macaques, and found that they showed high nucleotide diversity along with a large number of amino acid substitutions. These trends result in the occurrence of various divergent alleles of T2Rs within the primate populations and in heterozygous individuals who might have the ability to taste a broader range of substances. In addition, we revealed that phenotypic polymorphism of sensitivity to PTC was caused by the independent mutations of T2R38 in humans, chimpanzees and macaques.

苦味是由属于G蛋白偶联受体的T2R基因介导的。我们研究了黑猩猩和日本猕猴的功能性T2 R基因的种内变异，发现它们显示出高的核苷酸多样性沿着大量的氨基酸替换。这些趋势导致在灵长类动物种群和杂合子个体中出现各种不同的T2R等位基因，这些个体可能具有品尝更广泛物质的能力。此外，我们发现，PTC敏感性的表型多态性是由T2R38的独立突变在人类，黑猩猩和猕猴。

项目成果

Identification of non-taster Japanese macaques for a specific bitter taste

• DOI: 10.1007/s10329-010-0209-3
• 发表时间: 2010-07
• 期刊: Primates
• 影响因子: 1.7
• 作者: N. Suzuki;T. Sugawara;A. Matsui;Yasuhiro Go;H. Hirai;H. Imai

霊長類味覚受容体の進化

灵长类味觉受体的进化

• 发表时间: 2012
• 作者: Oishi M;Ogihara N;Endo H;Komiya T;Kawada S;Tomiyama T;Sugiura Y;Ichihara N;Asari M;T.Mikami;今井啓雄
• 通讯作者: 今井啓雄

DIVERSIFICATION OF BITTER TASTE RECEPTOR GENE FAMILY IN CHIMPANZEES

黑猩猩苦味受体基因家族的多样化

• 发表时间: 2010
• 作者: 勝村啓史;尾田正二;三谷宏志;河村正二;太田博樹;山川智子;Tohru Sugawara
• 通讯作者: Tohru Sugawara

Diversification of Bitter Taste Receptor Gene Family in Western Chimpanzees

• DOI: 10.1093/molbev/msq279
• 发表时间: 2011-02-01
• 期刊: MOLECULAR BIOLOGY AND EVOLUTION
• 影响因子: 10.7
• 作者: Sugawara, Tohru;Go, Yasuhiro;Imai, Hiroo
• 通讯作者: Imai, Hiroo

Reverse Evolution in RH1 for Adaptation of Cichlids to Water Depth in Lake Tanganyika

• DOI: 10.1093/molbev/msq344
• 发表时间: 2011-06-01
• 期刊: MOLECULAR BIOLOGY AND EVOLUTION
• 影响因子: 10.7
• 作者: Nagai, Haruka;Terai, Yohey;Okada, Norihiro
• 通讯作者: Okada, Norihiro