Food-derived components that enhances neuronal differentiation

神经营养因子，如神经生长因子（NGF），在中枢和外周系统中神经元的生长、发育、存活和功能维持中起重要作用。它们还可以防止在各种应激条件下的神经元细胞死亡，例如缺血和神经退行性疾病。在本研究中，我们确定了白藜芦醇作为一种食物源性神经生长促进剂。白藜芦醇强烈增强神经突起的生长和神经丝的表达引起的低浓度的神经生长因子，单独是不足以诱导神经元分化。此外，我们还鉴定了花生四烯酸代谢产物15-脱氧-△ 12，14-前列腺素J2（15 d-PGJ 2）作为神经突生长的促进剂，并探讨了15 d-PGJ 2促进神经突生长的机制。15 d-PGJ 2通过Ca ~（2+）内流促进神经突的发生

Neurotrophins, such as the nerve growth factor (NGF), play an essential role in the growth, development, survival and functional maintenance of neurons in the central and peripheral systems. They also prevent neuronal cell death under various stressful conditions, such as ischemia and neurodegenerative disorders. In the present study, we identified resveratrol as one of the food-derived neuritogenic enhancers. Resveratrol strongly enhanced the neurite outgrowth and neurofilament expression elicited by a low-concentration of NGF that alone was insufficient to induce neuronal differentiation. In addition, it was suggested that resveratrol-enhanced neuritogenesis was dependent on p38 MAP kinase.We also identified 15-deoxy-△12,14-prostaglandin J2 (15d-PGJ2), an arachidonic acid-derived metabolite, as neuritogenic enhancer and determined the mechanism of 15d-PGJ2-enhanced neurite outgrowth. 15d-PGJ2 significantly enhanced the neuritogenesis via Ca2+influx