Role of oxidative stress and inflammation on the deficits of memory and learning in mouse model for Down syndrome

氧化应激和炎症对唐氏综合症小鼠模型记忆和学习缺陷的作用

• 批准号: 22790091
• 负责人: ISHIHARA Keiichi
• 金额: $ 2.58万
• 依托单位: Kyoto Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790091/
• 关键词: ダウン症候群; 炎症; 酸化ストレス; マウスモデル

In the present study, we found that lipid peroxidation and inflammation were induced in the brain of mouse model for Down syndrome(DS) at 3 months of age. Although increased lipid peroxidation was not detected in the brain of 1 month-old mouse model for DS, increased inflammation was observed in embryonic mouse brain with DS, suggesting that increased lipid peroxidation and inflammation would be independent in each other. Neuroinflammation in the DS brain could be therapeutic target for developmental retardation of DS brain and memory and learning impairment in DS patients.

在本研究中，我们发现3月龄的唐氏综合征(DS)小鼠的脑组织发生了脂质过氧化和炎症反应。虽然1月龄DS模型小鼠脑内未检测到脂质过氧化反应增强，但在DS小鼠胚胎脑组织中观察到炎症反应增加，提示脂质过氧化反应增强与炎症反应可能是相互独立的。DS脑内的神经炎症可作为DS脑发育迟缓和学习记忆障碍的治疗靶点。

项目成果

Triacylglycerol deposition with group IVC phospholipase A2 expression in oleate- and linoleate-stimulated Huh-7 hepatocytes.

• DOI: 10.1248/bpb.34.191
• 发表时间: 2011-02
• 期刊: Biological & pharmaceutical bulletin
• 影响因子: 2
• 作者: K. Ishihara;Kengo Tachibana;Asuka Kuroda;Ayano Terakawa;S. Baba;Shiho Kanai;S. Akiba

Regulation of macrophage differentiation and polarization by group IVC phospholipase A_2. Biochem

IVC 组磷脂酶 A_2 对巨噬细胞分化和极化的调节。

• 发表时间: 2011
• 期刊: Biophys. Res. Commun
• 作者: Ishihara K.;Kuroda A.;Sugihara K.;Kanai S.;Nabe T.;Akiba S
• 通讯作者: Akiba S

ダウン症候群モデルマウスの異常表現型解析

唐氏综合症模型小鼠异常表型分析

• 发表时间: 2012
• 作者: 石原慶一;金井志帆;秋葉聡;山川和弘
• 通讯作者: 山川和弘

Regulation of macrophage differentiation and polarization by group IVC phospholipase A2

• DOI: 10.1016/j.bbrc.2011.11.034
• 发表时间: 2011-12-16
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Ishihara, Keiichi;Kuroda, Asuka;Akiba, Satoshi
• 通讯作者: Akiba, Satoshi