Analysis of the lysosomal enzyme metabolizing the anti-inflammatory lipid, N-acylethanolamine

在本研究中，我们分析了代谢抗炎脂质的酶，n -酰基乙醇胺（NAE）。我们发现nae -水解酸酰胺酶（NAAA）是一种降解NAEs的溶酶体酶，可被内源性物质如磷脂和二氢硫辛酸激活，并且几种亲脂胺是NAAA的新抑制剂。此外，我们认为肿瘤抑制因子HRASLS家族的成员HRASLS1通过其n -酰基转移酶活性参与了NAE的生物合成。

In the present study, we analyzed enzymes metabolizing the anti-inflammatory lipid, N-acylethanolamine(NAE). We found that NAE-hydrolyzing acid amidase(NAAA), a lysosomal enzyme degrading NAEs, is activated by endogenous substances such as some phospholipids and dihydrolipoic acid and that several lipophilic amines are new inhibitors of NAAA. Furthermore, we suggested that HRASLS1, a member of the tumor suppressor HRASLS family, is involved in NAE biosynthesis by its N-acyltransferase activity.