Molecular mechanism of the spontaneous regression of neuroblastoma

神经母细胞瘤自发消退的分子机制尚不清楚。我之前已经证明了LAPTM5（溶酶体相关蛋白多跨膜5）蛋白积累介导的细胞死亡与NBs的肿瘤消退密切相关。在这项资助的支持下，我明确了该表达的转录和翻译后调控机制，并提出其机制失调可能是laptm5介导NB细胞死亡。

It is unknown for the molecular mechanism of spontaneous regression of neuroblastoma(NB). I have previously demonstrated that the cell death mediated by accumulation of LAPTM5(lysosomeal-associated protein multispanning membrane 5) protein was closely associated with tumor regression of NBs. With the support of this grant, I clarified the mechanism of transcriptional and post-translational regulation for the expression, and suggested that the dysregulation of its mechanism may LAPTM5-mediated cell death in NB cells.