The host RNA uptake related gene in Schistosoma japonicum

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Schistosomes induce the RNA interference(RNAi) using long dsRNA in soaking method, such as C. elegans. It is previously reported that schistosomes incorporate the dsRNA, including host derived RNA. To understand the relationships between RNA uptake and parasitism, sid-1 gene, related to RNAi machinery, was investigated. The mRNA of sid-1 was increased in the larval stage after the invasion to the host, and was regulated by the induction of long dsRNA. However, the schistosomes knocked down with sid-1 siRNA, were not effects to RNAi machinery, dsRNA uptake, and parasitism in the host. These mean that schistosomes may have the distinct RNAi machinery.