Analysis of human cell death mechanism caused by ADP-ribosyltransferase Cholix toxin

胆毒素（Cholix）是由霍乱弧菌产生的一种新型adp -核糖基转移酶细胞毒素。eef2 - adp核糖基化诱导的细胞死亡途径在不同细胞类型中存在差异。胆碱诱导的HeLa细胞凋亡依赖于半胱天冬酶的激活，该激活受线粒体依赖性和非依赖性途径的调节。综上所述，炎性caspase和caspase-8参与了线粒体信号和其他caspase的激活。

Cholix toxin (Cholix) is a novel ADP-ribosyl transferase cytotoxin produced by Vibrio cholerae. Cell death pathway induced by eEF2-ADP-ribosylation differs in various cell types. Cholix-induced apoptosis in HeLa cells is dependent on caspase activation, which is regulated by both mitochondria-dependent and -independent pathways. In conclusion, inflammatory caspases and caspase-8 were responsible for both mitochondrial signals and other caspase activation.