Identification and characterization of factors that regulate EB virus reactivation from latency

调节 EB 病毒潜伏期重新激活的因素的鉴定和表征

• 批准号: 22790448
• 负责人: MURATA Takayuki
• 金额: $ 2.58万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790448/
• 关键词: EBウイルス; 再活性化; ウイルス; 癌; 低酸素; SUMO化

Epstein-Barr(EB) virus is a causative agent of serious diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal cancer, or gastric cancer. Changes of viral lifecycles, such as reactivation from latency, have been implicated in the severity or state of the diseases, and thus analyzing mechanisms of such transitions is of importance. We here newly identified transcription factors that regulate the virus reactivation, and observed epigenetic alterations mediated by those factors(Murata et al., JBC 2010, 2011, Murata et al., JV 2012).

EB病毒是传染性单核细胞增多症、伯基特淋巴瘤、鼻咽癌或胃癌等严重疾病的病原体。病毒生命周期的变化，如从潜伏期重新激活，已经涉及疾病的严重程度或状态，因此分析这种转变的机制是重要的。我们在此新鉴定了调节病毒再活化的转录因子，并观察到由这些因子介导的表观遗传改变（Murata et al.，JBC 2010，2011，Murata等人，JV 2012）。

项目成果

Unexpected instability of family of repeats (FR), the critical cis-acting sequence required for EBV latent infection, in EBV-BAC systems.

• DOI: 10.1371/journal.pone.0027758
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kanda T;Shibata S;Saito S;Murata T;Isomura H;Yoshiyama H;Takada K;Tsurumi T
• 通讯作者: Tsurumi T

EBウイルスの再活性化を誘導する細胞性因子のスクリーニング

筛选诱导 EB 病毒重新激活的细胞因子

• 发表时间: 2010
• 作者: 村田貴之;鶴見達也;村田貴之;村田貴之
• 通讯作者: 村田貴之

The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene.

• DOI: 10.1371/journal.pone.0011901
• 发表时间: 2010-07-30
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Isomura H;Stinski MF;Murata T;Nakayama S;Chiba S;Akatsuka Y;Kanda T;Tsurumi T
• 通讯作者: Tsurumi T

Screening of cellular factors that enhance reactivation from the EBV latency

筛选增强 EBV 潜伏期再激活的细胞因子

• 发表时间: 2010
• 作者: Murata T;Tsurumi T;Murata T
• 通讯作者: Murata T

Screening of cellular factors that enhance reactivation of Epstein-Barr virus from latency

筛选增强 Epstein-Barr 病毒潜伏期再激活的细胞因子

• 发表时间: 2010
• 作者: 村田貴之;鶴見達也
• 通讯作者: 鶴見達也