Amelioration of AngiotensinII-induced salt-sensitive hypertension by L-FABP in proximal tubules

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Recent findings indicated that inappropriate activation of the intrarenal renin-angiotensin system(RAS) induces reactive oxygen species production, which may contribute to salt-sensitive hypertension. On the other hand, L-FABP is expressed in renal proximal tubules in humans and may play an endogenous antioxidant role. The present study is to examine the antioxidative effect of L-FABP on salt-sensitive hypertension. The present findings indicated that L-FABP in proximal tubules may protect against AngII-induced SSHT in combination with attenuation of intrarenal RAS activation, oxidative stress. Therefore, L-FABP of proximal tubules may play a pathological role in SSHT.