Development of innovative biochip for controlling cell adhesion

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This paper presents development of a technique to control cell adhesion usingan array of magnetic microbeads. Using MEMS techniques, we fabricated an array of microholes (3 μmin diameter and 2 μm in depth) on the surface of a glass substrate, to trap magnetic microbeads (2.8 μmin diameter) in the microholes. The magnetic microbeads were coated with fibronectin prior to theloading. A permanent magnet was placed under the substrate and was used to trap microbeads into themicroholes. After 24 hours incubation, it was observed that cells attached only to the magneticmicrobeads, but not to the other parts of the glass surface.