Analyses of the mechanism of hypertension by means of optical imaging

从心血管中枢功能异常的角度探讨高血压的发病机制。分离E14-E16对照组和自发性高血压大鼠(SHR)胚胎的迷走神经和舌咽神经的脑干标本。用多点光学成像方法检测迷走神经或舌咽神经刺激的神经反应。通过对信号波形的分析，我们识别出与迷走神经和舌咽神经相关的运动和感觉核团。在孤束核内，兴奋性突触后电位(EPSP)的发育过程在对照胚胎和SHR胚胎中相似。

We studied the mechanism of hypertension in view of functional abnormality of the cardiovasucular center. Brainstem preparations with the vagus and glossopharyngeal nerves attached were dissected from E14-E16 control and spontaneous hypertensive rat (SHR) embryos. Neural responses to vagus or glossopharyngeal nerve stimulation were detected by means of multiple-site optical imaging. From the analysis of signal waveforms, we identified motor and sensory nuclei related to the vagus and glossopharyngeal nerves. In the nucleus of the tractus solitarius, developmental processes of the excitatory postsynaptic potential (EPSP) were similar between the control and SHR embryos.