Analysis of the relationship between Chemotaxis system and rotational motion of motors of the bacteria by the multi-motor measurements

细菌鞭毛马达是一种直径仅为40nm的马达，利用离子流每秒旋转约1000转。E.大肠杆菌大约有5条细丝，并通过化学感受器的信息改变这些方向。虽然，细菌具有高度复杂的信号转导，能量转换和合作系统，但我们有一些关于它们的信息。本研究通过纳米测量系统和成像系统的融合，研究了各个马达之间的相互关系、马达对化学信号的响应、马达对外界刺激的响应、笼状化合物的局部刺激与细胞响应之间的相关性以及基因表达调控与马达旋转运动之间的相关性，我们发现每个电机的切换存在相关性，并且这个定时具有一定的延迟。这种延迟依赖于每个电机的位置，这表明来自细胞极点的信息是以波的形式传播的。使用笼状化合物，电机的旋转方向，CW偏置被改变。

The bacteria flagellar motor is a motor of which diameter is only 40nm, and rotate about 1000 rotations per second using flow of ions. E. Coli has about 5 filaments and changes these directions by the information from chemo-receptors. Although, the bacteria has works with highly sophisticated signal transduction, energy conversion, and cooperation system, we have a few information about them. In this research, by fusing nano-measurements system and imaging system, the relationship between each motors, the response of the motors by the chemo-signals, the response of the motor by the external stimuli, the correlation between the local stimulation by the caged-compounds and the response of the cell and the correlation between the regulation of the gene expression an rotational motion of the motor.Using these techniques, we found that there were correlations of the switching of each motors, and this timing has some delay. This delay was depended on the position of the each motors, that suggested that the information from the cell pole propagated as wave. Using caged-compounds, the rotational directions of the motors, CW-bias were changed.