Molecular Epidemiological Studies using Helicobacter pylori

在本研究中，我们从冲绳分离的幽门螺杆菌中提取DNA，并使用7个管家基因进行毒力因子（cagA和vacA）的基因型和多位点序列分型。冲绳胃癌的低患病率可能是由于低毒力菌株（西方型cagA和cagA阴性菌株，vacA s2m2型）的高患病率。冲绳的这些菌株的起源可能与西方国家的不同，冲绳的这些菌株可能独立进化。

In this study, we extracted the DNA from Helicobacter pylori isolated in Okinawa, and performed the genotypes of virulence factors(cagA and vacA) and multilocus sequence typing using 7 housekeeping genes. Low prevalence of gastric cancer in Okinawa may result from the high prevalence of low virulent strains(Western-type cagA and cagA-negative strains, vacA s2m2 type). The origin of these strains in Okinawa may be different from those of Western countries, and these strains in Okinawa might evolve independently.