Elucidation of the role of Pin1 on the adipose differentiation

我们报道了Pin 1与Crtc 2结合并抑制CRE在肝脏中的转录和促凋亡活性。此外，Pin 1与IRS-1（一种主要的胰岛素受体底物）结合，并增强胰岛素诱导的代谢作用。Pin 1与IRS-1和Crtc 2的关联最终有助于将过量的营养物质掺入组织中，基于使用Pin 1的体外和体内过表达、基因沉默、特异性抑制剂和Pin 1敲除小鼠获得的数据系列。此外，还表明Pin 1对于前脂肪细胞向成熟脂肪细胞的分化也是必不可少的。

We reported that Pin1 binds to Crtc2 and suppresses CRE transcriptional and gluconeogenic activity in the liver. In addition, Pin1 associates with IRS-1, a major insulin receptor substrate, and enhances insulin-induced metabolic actions. The associations of Pin1 with IRS-1 and Crtc2 ultimately contribute to the incorporation of excess nutrients into tissues, based on a data series obtained using in vitro and in vivo over-expressions of Pin1, gene silencing, a specific inhibitor and Pin1 knock-out mice. In addition, it was shown that Pin1 is also indispensable for differentiation from pre-adipocytes into mature adipocytes.