Elucidation of the molecular mechanisms underlying insulin resistance and metabolic disorders using a proteomics technology

胰岛素通过多种信号转导蛋白和转录因子发挥代谢作用。在本研究中，我们开展了与代谢调节或胰岛素作用重要蛋白的结合蛋白的筛选工作。因此，我们发现Pin1可以调节IRS-1的磷酸化以及CRTC2的亚细胞分布。除了Pinl，还鉴定了几个重要的蛋白质组合，这将有助于开发治疗糖尿病的新药。

Insulin exerts its metabolic actions through many signal transduction proteins and transcription factor. In this study, we carried out the screening the binding proteins with the important proteins for the metabolic regulation or insulin action. As a result, we identified Pinl to regulate IRS-1 phosphorylation as well as the subcellular distribution of Crtc2. Besides Pinl, several important protein associations were identified, which would be useful for the development of a novel drug to treat diabetes mellitus.