Elucidation of the molecular mechanisms underlying insulin resistance and metabolic disorders using a proteomics technology

胰岛素通过多种信号转导蛋白和转录因子发挥其代谢作用。在本研究中，我们进行了筛选与代谢调节或胰岛素作用的重要蛋白质的结合蛋白。因此，我们鉴定了Pinl调节IRS-1磷酸化以及Crtc 2的亚细胞分布。除Pinl外，还鉴定了几种重要的蛋白质缔合物，这将有助于开发治疗糖尿病的新药。

Insulin exerts its metabolic actions through many signal transduction proteins and transcription factor. In this study, we carried out the screening the binding proteins with the important proteins for the metabolic regulation or insulin action. As a result, we identified Pinl to regulate IRS-1 phosphorylation as well as the subcellular distribution of Crtc2. Besides Pinl, several important protein associations were identified, which would be useful for the development of a novel drug to treat diabetes mellitus.