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The role of LH/hCG in uterine endometrium for fertility

The role of LH/hCG in uterine endometrium for fertility
LH/hCG 在子宫内膜中对生育的作用
批准号:
22659295
负责人:
MINEGISHI Takashi
金额:
$2.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We have detected LH/hCG receptor mRNA in the immature rat uterus by Northern blot and down-regulation of this receptor mRNA in the PMSG-hCG treated immature rats. Mvk, an LHR mRNA-binding protein, has been shown to accelerate LHR mRNA instability in the ovary. In the uterus, Mvk increased after PMSG treatment of immature rats and decreased after hCG treatment. The cultured uterus displayed an hCG concentration-dependent increase in cAMP production in medium. The immunohistochemical experiment showed that these receptor proteins are expressed in the epithelial cells of endometrium. These results suggest that functional LH/hCG receptors are present in the immature rat uterus and are down-regulated and up-regulated by signals resulting from hCG treatment.
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Clusterin expression inversely correlates with chemosensitivity and predicts poor survival in patients with locally advanced cervical cancer treated with cisplatin-based neoadiuvant chemotherapy and radical hysterectomy.
簇蛋白表达与化疗敏感性呈负相关,并预测接受基于顺铂的新辅助化疗和根治性子宫切除术治疗的局部晚期宫颈癌患者的生存率较差。
DOI: --
发表时间: 2010
期刊: Pathology oncology research
影响因子: --
作者: [Watari H, Kanuma T, Ohta Y, Hassan MK, Mitamura T, Hosaka M, Minegishi T, Sakuragi N., Watari Hidemichi]
通讯作者: Watari Hidemichi
DOI: --
发表时间: 2011
期刊: PTM:最新の疾患別治療マニュアル
影响因子: --
作者: [Kanao K, et al, 峯岸敬]
通讯作者: 峯岸敬
ラット卵巣LH受容体(LHR)の発現調節における、GRP78とmiRNAの関係について
关于GRP78与miRNA调控大鼠卵巢LH受体(LHR)表达的关系
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [吉原弘祐, 田中憲一, 他2名, 岩宗政幸]
通讯作者: 岩宗政幸
Downregulation of LH receptor mRNA in the rat uterus
大鼠子宫中 LH 受体 mRNA 的下调
DOI: 10.3892/mmr.2012.795
发表时间: 2012
期刊: Mol Med Report
影响因子: --
作者: [Kasahara Y, Kitahara Y, Nakamura K, Minegishi T.]
通讯作者: Minegishi T.
14
    Role of micro RNA on the Expression of Luteinizing Hormone-Human Chorionic Gonadotropin Receptor Messenger Ribonucleic Acid in rat ovary
    • 批准号:
      21390448
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.32万
    • 财政年份:
      2009
    • 负责人:
      MINEGISHI Takashi
    • 依托单位:
    Study for mechanism of gonadotropin action on follicular and oocyte maturation
    • 批准号:
      19390425
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.48万
    • 财政年份:
      2007
    • 负责人:
      MINEGISHI Takashi
    • 依托单位:
    FSH-R polymorphisms in women with infertility
    • 批准号:
      17390446
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.02万
    • 财政年份:
      2005
    • 负责人:
      MINEGISHI Takashi
    • 依托单位:
    Study for regulation of gonadotropin receptor and development of new ovulation induction method
    • 批准号:
      13470344
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.0万
    • 财政年份:
      2001
    • 负责人:
      MINEGISHI Takashi
    • 依托单位:
    海外基金