Structure and function of gonadotropin receptors

已经公布了两种不同的人促黄体生成素受体序列，不同的是在55-60位编码亮氨酸-谷氨酰胺的六个碱基对的插入。最近有人提出，这将反映人类基因组中存在两个促黄体生成素受体基因座。目前的结果表明，这两个序列在高加索人群中都以等位基因变体的形式存在。‘LQ变异体’和‘野生型’(αLQ)等位基因频率分别为0.26和0.74。相比之下，LQ等位基因在日本人群中几乎不存在。通过在COS-7细胞中瞬时表达对这两个等位基因的功能鉴定，没有发现两个受体在细胞表面的表达、cAMP的产生和对hCG/LH的敏感性方面的任何差异。

Two different human LH receptor sequences have been published, differing by a six-base pair insertion encoding Leu-Gln at position 55-60. It has recently been proposed that this would reflect the existence of two LH receptor loci in the human genome. The present results demonstrate that both sequences exist as allelic variants in the Caucasian population. Allelic frequency of 'LQ variant' and 'wild-type' (αLQ) allele are 0.26 and 0.74 respectively. In contrast, the LQ allele is virtually absent from the Japanese population. Functional characterization of both alleles by transient expression in COS-7 cells did not reveal any difference between the two receptors, neither for cell surface expression nor for cAMP production and sensitivity to hCG/LH.