Structure and function of gonadotropin receptors

两种不同的人类LH受体序列已被发表，其区别在于编码Leu-Gln的6碱基对插入在位置55-60。最近有人提出，这可能反映了人类基因组中存在两个LH受体位点。目前的结果表明，这两个序列在高加索人群中作为等位基因变体存在。“LQ变体”和“野生型”（αLQ）等位基因的等位频率分别为0.26和0.74。相比之下，LQ等位基因在日本人口中几乎是不存在的。通过在COS-7细胞中瞬时表达这两个等位基因的功能表征，无论是在细胞表面表达，还是在cAMP的产生和对hCG/LH的敏感性方面，两种受体之间都没有发现任何差异。

Two different human LH receptor sequences have been published, differing by a six-base pair insertion encoding Leu-Gln at position 55-60. It has recently been proposed that this would reflect the existence of two LH receptor loci in the human genome. The present results demonstrate that both sequences exist as allelic variants in the Caucasian population. Allelic frequency of 'LQ variant' and 'wild-type' (αLQ) allele are 0.26 and 0.74 respectively. In contrast, the LQ allele is virtually absent from the Japanese population. Functional characterization of both alleles by transient expression in COS-7 cells did not reveal any difference between the two receptors, neither for cell surface expression nor for cAMP production and sensitivity to hCG/LH.