Possibility of QX-314 as a novel therapeutic drug for neuropathic pain

新型局麻药QX-314具有钠通道阻断作用，这种作用要求它通过神经元表面的TRIPV1通道进入神经元，并在神经元内部产生阻断作用。因此，我们研究了QX-314抗伤害性作用的可能性，并观察了QX-314对切断下牙槽神经引起的大鼠戒断阈值的影响。结果表明，QX-314与辣椒素联用可提高小鼠的致死阈值。这与损伤的三叉神经内TRIPV1通道增加的组织学结果一致。提示QX-314有可能作为神经病理性疼痛的治疗工具。

A novel local anesthetic, QX-314 is known to have an effect of Na+ channel blockade.This action requires it to enter through TRIPV1 channel on the surface of the neuron and make a blockade action inside the neuron. Thus, we aimed to study the possibility of QX-314 in anti-nociceptive effect and investigated the effects of QX-314 on the withdraw threshold which was decreased by a resection of inferior alveolar nerve in the rats. The results were that QX-314 using together with capsaicin, the threshold became to be elevated. This was consistent with histological findings that TRIPV1channels increased in the injured trigeminal nerve. These suggested that QX-314 has a potential to be used as a therapeutic tool for neuropathic pain.