Possibility of QX-314 as a novel therapeutic drug for neuropathic pain

QX-314是一种新型局部麻醉剂，已知具有Na+通道阻断作用。这一作用需要它通过神经元表面的TRIPV1通道进入，并在神经元内部产生阻断作用。因此，我们旨在研究QX-314抗伤害性作用的可能性，并研究QX-314对切除下肺泡神经后大鼠的撤退阈值的影响。结果表明，QX-314与辣椒素联合使用后，其阈值有所升高。这与tripv1通道在损伤三叉神经中增加的组织学结果一致。这表明QX-314有潜力作为神经性疼痛的治疗工具。

A novel local anesthetic, QX-314 is known to have an effect of Na+ channel blockade.This action requires it to enter through TRIPV1 channel on the surface of the neuron and make a blockade action inside the neuron. Thus, we aimed to study the possibility of QX-314 in anti-nociceptive effect and investigated the effects of QX-314 on the withdraw threshold which was decreased by a resection of inferior alveolar nerve in the rats. The results were that QX-314 using together with capsaicin, the threshold became to be elevated. This was consistent with histological findings that TRIPV1channels increased in the injured trigeminal nerve. These suggested that QX-314 has a potential to be used as a therapeutic tool for neuropathic pain.