Telencephalin binds to vitronectin and regulates synapse formation

我报告了端脑素是神经元树突上一种新的玻璃连结蛋白受体的鉴定。玻璃连结素包被的微球诱导培养的海马神经元树突上端脑素的积聚和吞噬杯状质膜突起的形成。Vitronectin缺陷小鼠在海马CA1锥体神经元中表现出明显的脊柱头增大。这些结果表明，玻璃连结蛋白及其神经元受体端脑素在脊柱形态发生中起着关键作用。

I report the identification of telencephalin as a novel vitronectin receptor on neuronal dendrites. Vitronectin-coated microbeads induce the accumulation of telencephalin and the formation of phagocytic cup-like plasma membrane protrusions on dendrites of cultured hippocampal neurons. Vitronectin-deficient mice displays marked enlargement of spine heads in hippocampal CA1 pyramidal neurons. These results suggest that the vitronectin and its neuronal receptor telencephalin play a pivotal role in spine morphogenesis.