Tumorigenesis triggered by the misregulation of the Wnt signaling pathways in mitosis

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One of the Wnt signaling pathways, theβ-catenin-dependent pathway contributes to G1/S progression through transcriptional activation, and mutations in the genes encoding the pathway trigger tumorigensis. However, involvement of the Wnt signaling pathways in mitotic progression remains unclear. We found that the components of theβ-catenin-dependent pathway regulate spindle orientation in metaphase, and other Wnt signaling pathways, the-βcatenin-independent pathway controls the completion of cytokinetic abscission. Our findings suggest that the Wnt signaling pathways govern multiple events in mitosis.