Tumorigenesis triggered by the misregulation of cell polarity associated with cell cycle

与细胞周期相关的细胞极性失调引发的肿瘤发生

• 批准号: 24700980
• 负责人: KIKUCHI Koji
• 金额: $ 2.83万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700980/
• 关键词: 細胞運動; 前後極性; 上皮極性; 微小管動態; MAP7ファミリー; Wnt5aシグナル; Dvl2

The establishment and maintenance of cell polarity has a crucial role in multiple biological processes from chemotaxis to embryogenesis, and the abnormality of cell polarity promotes tumorigenesis. It is believed that cytoskeletal network between microtubule (MT) and filamentous actin plays an important role for the establishment and maintenance of cell polarity. However, molecular mechanisms of the cytoskeletal network still remain unclear. Here, we found that MT co-sedimented proteins, which we have previously identified, are involved in the establishment of cell polarity by regulating the cytoskeletal network.

细胞极性的建立和维持在从趋化到胚胎发生的多个生物过程中起着至关重要的作用，细胞极性的异常促进肿瘤的发生。微管（MT）和丝状肌动蛋白之间的细胞骨架网络对细胞极性的建立和维持起着重要作用。然而，细胞骨架网络的分子机制仍不清楚。在这里，我们发现我们之前发现的MT共沉积蛋白通过调节细胞骨架网络参与了细胞极性的建立。

项目成果

Wnt5a signaling controls cytokinesis by correctly positioning ESCRT-III at the midbody

• DOI: 10.1242/jcs.108142
• 发表时间: 2012-10-15
• 期刊: JOURNAL OF CELL SCIENCE
• 影响因子: 4
• 作者: Fumoto, Katsumi;Kikuchi, Koji;Kikuchi, Akira
• 通讯作者: Kikuchi, Akira

siRNA Screening Reveals the Involvement of MAP7 Family in Cell Polarity

siRNA 筛选揭示 MAP7 家族与细胞极性的关系

• 发表时间: 2013
• 作者: 菊池浩二;中西宏之
• 通讯作者: 中西宏之

MAP7 family proteins are involved in cell polarization by regulating the cytoskeletal network

MAP7 家族蛋白通过调节细胞骨架网络参与细胞极化

• 发表时间: 2012
• 作者: 菊池浩二;中西宏之
• 通讯作者: 中西宏之

siRNA Screening Reveals the Involvement of MAP7 Family in Cell Polarity.

siRNA 筛选揭示了 MAP7 家族与细胞极性的关系。

• 发表时间: 2013
• 作者: 末弘淳一;櫻井裕之;菊池浩二
• 通讯作者: 菊池浩二

MAP7ファミリーによる細胞極性の制御機構

MAP7家族对细胞极性的控制机制

• 发表时间: 2012
• 作者: 菊池浩二;中西宏之
• 通讯作者: 中西宏之