Tumorigenesis triggered by the misregulation of cell polarity associated with cell cycle

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The establishment and maintenance of cell polarity has a crucial role in multiple biological processes from chemotaxis to embryogenesis, and the abnormality of cell polarity promotes tumorigenesis. It is believed that cytoskeletal network between microtubule (MT) and filamentous actin plays an important role for the establishment and maintenance of cell polarity. However, molecular mechanisms of the cytoskeletal network still remain unclear. Here, we found that MT co-sedimented proteins, which we have previously identified, are involved in the establishment of cell polarity by regulating the cytoskeletal network.