Application of CXCR3 expression in T cells for early diagnostics and prevention of malignant mesothelioma

石棉相关性胸膜斑块和恶性间皮瘤患者外周血CD4T细胞CXCR3表达降低，仅恶性间皮瘤患者外周血中干扰素-γ表达降低。此外，体外研究表明，慢性接触石棉可促进IL-17的表达，抑制CXCR3和干扰素-γ的表达。这些结果提示，长期接触石棉可导致机体抗肿瘤免疫功能受损，促进肿瘤增殖。

The expression of CXCR3 in peripheral CD4+ T cells was decreased in asbestos-related patients with pleural plaque and malignant mesothelioma, and IFN-γexpression was impaired in only patients with malignant mesothelioma. Additionally, in vitro study showed that IL-17 expression was enhanced while CXCR3 and IFN-γexpression were suppressed by chronic exposure of CD4+ T cells to asbestos. These results suggested that chronic exposure to asbestos might induce impairment of antitumor immune function and promotion of tumor proliferation.