RNAi screening for genes involved in differentiation of embryonic stem cells into primordial germ cells.
RNAi screening for genes involved in differentiation of embryonic stem cells into primordial germ cells.
批准号:
22710197
负责人:
MAEDA Ikuma
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
We identified Max as a repressor of germ-cell-related genes in embryonic stem cells (ESCs)via RNAi screen. Transcriptome analysis revealed that Max knockdown (KD)in ESCs resulted in selective, global derepression of germ-cell-specific genes. Max interacted with histone H3K9 methyltransferases and associated with the promoter regions of germ-cell-specific genes in ESCs. In addition, Max-KD resulted in a decrease in histone H3K9 dimethylation at those promoter regions.
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科研奖励(0)
会议论文
体系的RNAiによるES細胞から始原生殖細胞への変換に関わる遺伝子群の探索
通过系统RNAi寻找参与ES细胞向原始生殖细胞转化的基因
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ikuma Maeda, Yuko Tokitake, Nathan Mise, Kuniya Abe, Toshiaki Noce, 前田郁麻]
通讯作者:
前田郁麻
Yasuhisa Matsui RNAi screening for genes involved in conversion of embryonic stem cells into primordial germ cells
Yasuhisa Matsui RNAi 筛选参与胚胎干细胞转化为原始生殖细胞的基因
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ikuma Maeda, Yuko Tokitake, Nathan Mise, Kuniya Abe, Toshiaki Noce]
通讯作者:
Toshiaki Noce
RNAi screening for genes involved in differentiation of embryonic stem cells into primordial germ cells.
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批准号:20710151
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2008
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负责人:MAEDA Ikuma
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依托单位:
海外基金