Molecular epidemiological elucidation of Japanese, American, and European gastric and colorectal carcinogenesis by integrated analysis of functional RNA and clinical application and cancer prevention

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We have done integrative analysis of miRNA alterations, including DNA methylation, miRNA expression, target tumor-related genes, and host SNP in Japanese, American, and European gastric and colorectal cancers. Alterations in the profiling of DNA methylation and miRNA expression were revealed. Based on the profiling results, alterations in the particular DNA methylation and miRNA were also revealed. Alterations in the non-coding DNA regions of tumor-related genes, such as 3'-UTR and 5'-UTR, were characterized. Finally, SNPs in the miRNA-related genes, such as pri-miR, pre-miR, miRNA-processing genes, and miRNA-binding sequences of tumor-related genes were characterized. These results are promising for the understanding of carcinogenesis and future clinical application.