Development of endoscopic molecular imaging diagnostic procedure for esophageal cancer using real-time virtual molecular biology
Development of endoscopic molecular imaging diagnostic procedure for esophageal cancer using real-time virtual molecular biology
批准号:
23650616
负责人:
YAMAMOTO Hiroyuki
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
本研究的目的是研究食管鳞状细胞癌(ESCC)中CpG岛甲基化的变化,并鉴定甲基化基因,阐明全基因组低甲基化在ESCC中的作用。从正常健康上皮到ESCC背景的非肿瘤上皮,到癌组织,全基因组CpG岛甲基化程度逐渐增加。肿瘤相关基因,特别是LRFN 5基因的CpG岛高甲基化,和全基因组低甲基化似乎在ESCC发病机制中起重要作用,与饮酒和/或吸烟习惯无关。
英文摘要
The aim of this study was to profile methylation changes and identify methylated genes and to clarify the role of genome-wide hypomethylation in esophageal squamous cell carcinoma(ESCC).The degree of genome-wide CpG islands methylation increased from the normal healthy epithelium,through the ESCC-background non-neoplastic epithelium,to the carcinoma tissues.CpG island hypermethylation of tumor-related genes,especially that of the LRFN5 gene,and genome-wide hypomethylation appear to play important roles in ESCC pathogenesis irrespective of drinking and/or smoking habits.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
MCA microarrayを用いたヒト食道扁平上皮癌におけるゲノムワイドメチル化異常の解析とI型膜貫通糖蛋白質LRFN5不活化の同定
利用 MCA 微阵列分析人食管鳞状细胞癌全基因组甲基化异常并鉴定 I 型跨膜糖蛋白 LRFN5 失活
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[伊藤美樹]
通讯作者:
伊藤美樹
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