Emerging pathophysiological roles of ganglioside GM3

点击翻译按钮获取中文摘要

We have found that CD8T cells express very high levels of o-series gangliosides, but on the other hand, CD4T cells preferably express a-series gangliosides. In the TCR dependent activation, CD4T cells selectively require a-series gangliosides, but CD8T cells do require only o-series gangliosides but not a-series gangliosides. Ganglioside GM3 synthase-deficient mice lacking a-series gangliosides neither exhibited the TCR-dependent activation of CD4T nor developed ovalbumin-induced allergic airway inflammation. These findings imply that the distinct expression pattern of ganglioside species in CD4T and CD8T cells define the immune function of each T cell subset.We also propose a working hypothesis =metabolic disorders, such as type2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides=.