Clinical application of the minimal residual disease monitoring in canine lymphoma

微小残留病监测在犬淋巴瘤中的临床应用

• 批准号: 23380182
• 负责人: TSUJIMOTO Hajime
• 金额: $ 11.65万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380182/
• 关键词: 動物; 犬; リンパ腫; 微小残存病変; 化学療法; 予後

Overall survival durations after standard chemotherapies have been reported as long as 1 year. In the present study, we assessed the efficacy of the chemotherapeutic protocols objectively by quantification of the minimal residual disease, MRD, after chemotherapy with real-time PCR. Through the results of MRD monitoring, we could propose several strategies to improve the chemotherapeutic protocols such as dose change of the drugs, requirement of the consolidation chemotherapy, and the necessity of the early re-induction chemotherapy during complete remission. The present studies were conceivably very helpful to improve the chemotherapeutic modalities for canine lymphoma as well as indicative of the usefulness of canine lymphoma as an animal model for human non-Hodgkin lymphoma.

据报道，标准化疗后的总生存期长达1年。在本研究中，我们通过实时荧光定量PCR对化疗后的微小残留病（MRD）进行量化，客观地评估化疗方案的疗效。通过MRD监测结果，我们可以提出药物剂量的改变、巩固化疗的需要、完全缓解期早期再诱导化疗的必要性等改进化疗方案的策略。可以想象，目前的研究非常有助于改善犬淋巴瘤的化疗方式，并表明犬淋巴瘤作为人类非霍奇金淋巴瘤动物模型的有效性。

项目成果

The prognostic significance of minimal residual disease in the early phases of chemotherapy in dogs with high-grade B-cell lymphoma

• DOI: 10.1016/j.tvjl.2012.07.013
• 发表时间: 2013-03-01
• 期刊: VETERINARY JOURNAL
• 影响因子: 2.2
• 作者: Sato, Masahiko;Yamzaki, Jumpei;Tsujimoto, Hajime
• 通讯作者: Tsujimoto, Hajime

Establishment of Five Canine Lymphoma Cell Lines and Tumor Formation in a Xenotransplantation Model

• DOI: 10.1292/jvms.12-0448
• 发表时间: 2013-04-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Umeki, Saori;Ema, Yasuo;Mizuno, Takuya
• 通讯作者: Mizuno, Takuya

Characterization of canine BCL6 cDNA and detection systems for its expression

犬 BCL6 cDNA 的表征及其表达检测系统

• DOI: 10.1016/j.vetimm.2010.08.009
• 发表时间: 2011
• 期刊: Vet.Immunol.Immunopathol.
• 作者: Sato;M.;Goto-Koshino;Y.;Kanemoto;H.;Mochizuki;H.;Fujino;Y.;Ohno;K.;Tsujimoto;H.
• 通讯作者: H.

イヌのリンパ腫治療の現状

犬淋巴瘤治疗现状

• 发表时间: 2012
• 作者: 上野山賀久;中村 翔;早川 由起;池上 花奈;冨川 順子;美辺 詩織;後藤 哲平;家田菜穂子; 田村 千尋;三寳 誠;平林 真澄;前多敬一郎;束村 博子;Fujii S and Shimizu K.;笠松雅彦ら;辻本元
• 通讯作者: 辻本元

犬のリンパ腫におけるGeneScanningを用いた微小残存病変検出に関する研究

GeneScanning检测犬淋巴瘤微小残留病的研究

• 发表时间: 2013
• 作者: 日吉沙綾;他
• 通讯作者: 他