Studies on the epigenetic regulations in neoplastic diseases of animals
Studies on the epigenetic regulations in neoplastic diseases of animals
批准号:
24658265
负责人:
TSUJIMOTO Hajime
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
Expressions of p16, p15, and p14 genes encoding CDK inhibitors (proteins that regulates cell cycle) and ABCB1 gene encoding one of the ABCD transporters (proteins that efflux drugs etc. from cells) were examined in canine lymphoma cells. Suppression of the expression of these genes via epigenetic regulations such as DNA methylation and histone H3 deacetylation was detected in a proportion of canine lymphoma cases. Moreover, treatment with epigenetic drugs to inhibit such regulations could restore their gene expression levels. The present study disclosed an important role of epigenetic regulation on the pathobiology of neoplastic diseases in animals.
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犬のリンパ系腫瘍細胞株におけるABCB1遺伝子のDNAメチル化およびヒストンアセチル化による発現制御に関する検討
DNA甲基化和组蛋白乙酰化对犬淋巴肿瘤细胞株ABCB1基因表达调控的研究
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[富安博隆, 後藤裕子, 藤野泰人, 大野耕一, 辻本元]
通讯作者:
辻本元
DOI:
10.1292/jvms.12-0448
发表时间:
2013-04-01
期刊:
JOURNAL OF VETERINARY MEDICAL SCIENCE
影响因子:
1.2
作者:
[Umeki, Saori, Ema, Yasuo, Mizuno, Takuya]
通讯作者:
Mizuno, Takuya
Modulation of the expression of ABCB1 and LRP genes by perifosine in canine lymphoma cell lines
哌立福辛对犬淋巴瘤细胞系 ABCB1 和 LRP 基因表达的调节
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Tomiyasu, H., Goto-Koshino, Y., Fujino, Y., Ohno, K. and Tsujimoto, H.]
通讯作者:
H.
犬リンパ腫症例において発現変動を示す血清中microRNAの同定
鉴定犬淋巴瘤病例中表达改变的血清 microRNA
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[藤原亜紀, 水谷格之, 五十嵐寛高, 後藤裕子, 高橋雅, 藤野泰人, 大野耕一, 佐々木典康, 辻本元]
通讯作者:
辻本元
GeneScanning analysis of clonal antigen receptor gene rearrangement in canine intestinal endoscopic biopsy specimens
犬肠内镜活检标本克隆抗原受体基因重排的基因扫描分析
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[S. Hiyoshi, K. Uchida, K. Nakashima, K. Fukushima, H. Kanemoto, Y. Goto, Y. Fujino, K. Ohno, H. Tsujimoto]
通讯作者:
H. Tsujimoto
共 9 条
Clinical application of the minimal residual disease monitoring in canine lymphoma
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批准号:23380182
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.65万
-
财政年份:2011
-
负责人:TSUJIMOTO Hajime
-
依托单位:
Development of autologous bone marrow transplantation therapy using hematopoietic stem cells in dogs
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批准号:19380175
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.73万
-
财政年份:2007
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负责人:TSUJIMOTO Hajime
-
依托单位:
Development of novel therapeutic strategies based on the molecular analyses of tumor cells in animal lymphomas
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批准号:17380186
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.18万
-
财政年份:2005
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负责人:TSUJIMOTO Hajime
-
依托单位:
Development of novel therapeutic strategies for AIDS by the molecular regulation strategies for feline immunodeficiency virus infection
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批准号:15380209
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.26万
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财政年份:2003
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负责人:TSUJIMOTO Hajime
-
依托单位:
Usefulness of tumor markers in veterinary medicine
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批准号:12460138
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.11万
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财政年份:2000
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负责人:TSUJIMOTO Hajime
-
依托单位:
Development of DNA vaccine therapy for allergic diseases in animals
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批准号:12556056
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.0万
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财政年份:2000
-
负责人:TSUJIMOTO Hajime
-
依托单位:
Fundamental Research on the Cat Genome Analysis
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批准号:10460138
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$2.62万
-
财政年份:1998
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负责人:TSUJIMOTO Hajime
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依托单位:
Development of Novel Therapies for Canine A topic Dermatitis
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批准号:10556070
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.87万
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财政年份:1998
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负责人:TSUJIMOTO Hajime
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依托单位:
A study on the prevention and treanment of feline immunodeficiency virus infection
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批准号:09460144
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.58万
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财政年份:1997
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负责人:TSUJIMOTO Hajime
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依托单位:
STUDIES ON THE MULTI-STEP TUMORIGENESIS IN MALI GNANT TUMORS IN ANI MALS
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批准号:07660417
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:TSUJIMOTO Hajime
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依托单位:
Aberration of oncogenes and tumor suppressor genes in hematopocetic tumors in animals
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批准号:04454121
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.71万
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财政年份:1992
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负责人:TSUJIMOTO Hajime
-
依托单位:
海外基金