Senescence-inducing stress modulates glycolysis and the Warburg effect

我们主要关注的是糖酵素PGAM的抗衰老作用。我们报道了衰老诱导应激下PGAM被致癌基因Mdm2泛素化（Mikawa et al JCB 2014）。我们还发现HNF-1是卵巢癌糖酵解的转录调节因子（Okamoto等人，molecular cancer, 2013）。我们报道了PGAM在体内损害线粒体呼吸（Okuda等人，PLOSONE 2013）。我们还发现PGAM在癌细胞中被乙酰化。我们最终生成了PGAM-TG小鼠。我们还报道了PGAM-TG mef的转化能力（Mikawa et al JCB 2014）。因此，我们通过对PGAM的分子研究揭示了Warburg效应的未知方面。

Our main concern is the senescence-bypassing effect of PGAM, glycolytic enzyme. We reported that PGAM is ubiquitinated by oncogene Mdm2 under senescence-inducing stress(Mikawa et al JCB 2014). We also identified HNF-1 as transcriptional regulator for glycolysis in ovarian cancer(Okamoto et al, Molecu Carci 2013). We reported PGAM impairs mitochondrial respiration in vivo(Okuda et al, PLOSONE 2013). We also found that PGAM is acetyalted in cancer cells. And We finally generated PGAM-TG mice. We also reported transforming ability of MEFs from PGAM-TG (Mikawa et al JCB 2014). Thus we disclosed unknown aspect of the Warburg effect through molecular investigation of PGAM.