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Construction of predictive algorithm for therapeutic effect and exploration of molecular targets in esophageal cancer by the next-generation integrated genome analysis

Construction of predictive algorithm for therapeutic effect and exploration of molecular targets in esophageal cancer by the next-generation integrated genome analysis
新一代整合基因组分析构建食管癌治疗效果预测算法及探索分子靶点
批准号:
23390325
负责人:
IMOTO Issei
金额:
$12.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31

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中文摘要
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英文摘要
In order to make personalized medicine for esophageal squamous cell carcinoma (ESCC) , omics data were obtained from tumor samples with detailed clinical data in patients with ESCC treated by sufficiently systematized protocols through next generation sequencing- and microarray-based methods, and integrated. Through this approach, we constructed algorisms to perform the estimation of malignancy and prognosis of ESCC using molecular markers. In addition we identified novel candidate genes for a diagnostic, prognostic, prophylactic and/or therapeutic target in ESCC as well as other cancers, indicating our approach to be useful and widely applicable for various types of cancers.
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33
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    • 批准号:
      16K15618
    • 项目类别:
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    • 项目类别:
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