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Development and application of high-density genomic microarray system as a tool for human genome structural variation

Development and application of high-density genomic microarray system as a tool for human genome structural variation
高密度基因组微阵列系统作为人类基因组结构变异工具的开发与应用
批准号：
17019014
负责人：
IMOTO Issei
金额：
$40.77万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2005
资助国家：
日本
项目状态：
已结题
起止时间：
2005 至 2009
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17019014/
关键词：
ヒトゲノムアレイCGHゲノム構造異常先天異常染色体ゲノムアレイCGH法BACアレイ潜在的コピー数異常Copy-number variation (CNV)遺伝疾患ゲノムコピー数異常Copy number variationゲノム一次構造異常癌

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中文摘要
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英文摘要
In order to identify genes related to pathogenesis and progression of human diseases, we developed various genomic DNA-array platforms as analytical tools for structural human genome variations, and performed analyses of cryptic copy-number alterations in patients with multiple congenital anomaly/mental retardation (MCA/MR) using these tools. Through systematic array-assisted approach and additional analyses of genes located within regions with copy-number variations, we established technical bases of genomic arrays as diagnostic tools and identified various disease-related regions/genes in patients with MCA/MR.
期刊论文(51)
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会议论文
Construction of a high-density and high-resolution human chromosome Xarray for comparative genomic hybridization analysis.
构建高密度、高分辨率的人类染色体 X 阵列，用于比较基因组杂交分析。
DOI： --
发表时间： 2007
期刊： J Hum Genet. 52
影响因子： --
作者： [Hayashi S, Mizutani S, et. al.]
通讯作者： et. al.
The CASK gene harbored in a deletion detected by array-CGH as a potential candidate for a gene causative of X-linked dominant mental retardation
DOI： 10.1002/ajmg.a.32433
发表时间： 2008-08-15
期刊： AMERICAN JOURNAL OF MEDICAL GENETICS PART A
影响因子： 2
作者： [Hayashi, Shin, Mizuno, Seiji, Inazawa, Johji]
通讯作者： Inazawa, Johji
先天性異常症の染色体欠失の検出方法
如何检测先天性异常的染色体缺失
DOI： --
发表时间： 2008
期刊：
影响因子： --
作者： []
通讯作者：
RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest
DOI： 10.1038/sj.onc.1210148
发表时间： 2007-02-22
期刊： ONCOGENE
影响因子： 8
作者： [Saigusa, K., Imoto, I., Inazawa, J.]
通讯作者： Inazawa, J.
共 38 条
    Characterization of the esophageal carcinogenesis-promoting molecular switch existing inside the isoform of RNA-binding protein
    • 批准号：
      16K15618
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.16万
    • 财政年份：
      2016
    • 负责人：
      IMOTO Issei
    • 依托单位：
      The University of Tokushima
    Optimization of therapeutic strategy for esophageal squamous cell carcinoma based on modeling of intratumoral heterogeneity using omics data and genome editing
    • 批准号：
      26293304
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.23万
    • 财政年份：
      2014
    • 负责人：
      IMOTO Issei
    • 依托单位：
      The University of Tokushima
    Molecular genetic analysis of atherosclerosis and atrial thrombosis rat model spontaneously induced by hypoactivity
    • 批准号：
      25560368
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.5万
    • 财政年份：
      2013
    • 负责人：
      IMOTO Issei
    • 依托单位：
      The University of Tokushima
    Construction of systematic tools forgenome analysesto determinegenes responsible for various disease model in rats
    • 批准号：
      24650238
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.5万
    • 财政年份：
      2012
    • 负责人：
      IMOTO Issei
    • 依托单位：
      The University of Tokushima
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