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Identification of target genes for esophageal cancers through integrative analysis of genomic alterations and oncogene addiction

Identification of target genes for esophageal cancers through integrative analysis of genomic alterations and oncogene addiction
通过基因组改变和癌基因成瘾的综合分析鉴定食管癌的靶基因
批准号:
20591564
负责人:
IMOTO Issei
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In order to identify target tumor-related genes for establishing molecular targeting therapy in patients with esophageal squamous-cell carcinoma, we integrated detailed information of genomic/epigenomic alterations in tumors, functional addiction of tumor cells to candidate target genes (oncogene addiction), and clinicopathological significance of altered expression status of those genes. Using this approach, we successfully identified a number of possible novel onocogene and tumor suppressor genes, which may be useful therapeutic as well as diagnostic targets for esophageal cancers.
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会议论文
癌の検出方法および抑制方法
如何检测和控制癌症
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: []
通讯作者:
DOI: 10.1158/0008-5472.can-07-5194
发表时间: 2008-04-01
期刊: CANCER RESEARCH
影响因子: 11.2
作者: [Kozaki, Ken-ichi, Imoto, Issei, Inazawa, Johji]
通讯作者: Inazawa, Johji
食道扁平上皮癌において高頻度に発現抑制を受ける新規癌抑制遺伝子候補Protocadherin 17(PCDH17)
原钙粘蛋白 17 (PCDH17),一种新型抑癌基因候选物,其表达在食管鳞状细胞癌中经常受到抑制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [井本逸勢, 春木茂雄, 小崎健一, 松井毅, 河内洋, 小松周平, 村松智輝, 嶋田裕, 河野辰幸, 稲澤譲治]
通讯作者: 稲澤譲治
DOI: 10.1111/j.1349-7006.2008.00779.x
发表时间: 2008-05-01
期刊: CANCER SCIENCE
影响因子: 5.7
作者: [Suzuki, Ayako, Shibata, Tatsuhiro, Imoto, Issei]
通讯作者: Imoto, Issei
25
    Characterization of the esophageal carcinogenesis-promoting molecular switch existing inside the isoform of RNA-binding protein
    • 批准号:
      16K15618
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.16万
    • 财政年份:
      2016
    • 负责人:
      IMOTO Issei
    • 依托单位:
    Optimization of therapeutic strategy for esophageal squamous cell carcinoma based on modeling of intratumoral heterogeneity using omics data and genome editing
    • 批准号:
      26293304
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.23万
    • 财政年份:
      2014
    • 负责人:
      IMOTO Issei
    • 依托单位:
    Molecular genetic analysis of atherosclerosis and atrial thrombosis rat model spontaneously induced by hypoactivity
    • 批准号:
      25560368
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2013
    • 负责人:
      IMOTO Issei
    • 依托单位:
    Construction of systematic tools forgenome analysesto determinegenes responsible for various disease model in rats
    • 批准号:
      24650238
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      IMOTO Issei
    • 依托单位:
    海外基金