Membranous mucin expression in oral squamous cell carcinoma and its clinical significance

MUC 1和MUC 4粘蛋白是高分子量糖蛋白，在正常生理条件下有助于保护和润滑管腔表面。本研究的目的是评估口腔鳞状细胞癌（OSCC）患者MUC 1和MUC 4表达的预后意义。MUC 1和MUC 4的表达与肿瘤的侵袭性密切相关。在这两种粘蛋白中，表达的患者的总生存率和无病生存率明显低于不表达的患者。此外，这些表达被发现是一个独立的区域淋巴结转移的危险因素。综上所述，这些结果表明，口腔鳞状细胞癌显示阳性粘蛋白表达的患者应仔细随访，MUC 1/MUC 4免疫组化是肿瘤侵袭性的有力指标，可以预测随后的淋巴结转移和口腔鳞状细胞癌患者的预后。

MUC1 and MUC4 mucins are high molecular weight glycoproteins and help to protect and lubricate luminal surfaces under normal physiological conditions. The objective of the current study was to evaluate the prognostic significance of MUC1 and MUC4 expression in patients with oral squamous cell carcinoma (OSCC). Both MUC1 and MUC4 expression were found to be significantly correlated with tumor aggressiveness. In both mucins, the overall survival and disease-free survival rates were significantly worse for patients with expression compared with those without expression. In addition, these expressions were found to be an independent risk factor for subsequent regional lymph node metastasis. Taken together, these results suggest that patients with OSCC showing positive mucin expression should be followed up carefully, and that MUC1/MUC4 immunohistochemistry is a powerful indicator for tumor aggressiveness and can predict subsequent nodal metastasis and outcomes for patients with OSCC.