ELECTRON MICROSCOPIC STUDY ON ORAL LESIONS OF HIV-INFECTION

HIV 感染口腔病变的电子显微镜研究

• 批准号: 09672058
• 负责人: SUGIHARA Kazumasa
• 金额: $ 1.79万
• 依托单位: KAGOSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672058/
• 关键词: HUMAN IMMUNODEFICIENCY VIRUS; ORAL LESIONS; ELECTRON MICROSCOPY; HIV-ASSOCIATED PERIODONTAL DISEASE; ヒト免疫不全ウィルス(HIV); 口腔カンジタ症; HIV歯周疾患; ヒト免疫不全ウイルス(HIV); 口腔カンジダ症

ORAL LESIONS STRONGLY ASSOCIATED WITH HIV INFECTION ARE ORAL CANDIDIASIS, ORAL HAIRY LEUKOPLAKIA, INTRAORAL KAPOSI'S SARCOMA, NON-HODGKIN LYMPHOMA AND HIV-ASSOCIATED PERIODONTAL DISEASE.WE INVESTIGATED ULTRASTRUCTURAL FINDINGS OF THE GINGIVA DIAGNOSED PERIODONTITIS AND ACUTE NECROTIZING ULCERATIVE GINGIVITIS IN HIV-INFECTED PATIENTS. IN THE TISSUE SUFFERED FROM PERIODONTITIS, EPITHELIAL CELLS WERE EDEMATOUS. NEITHER VIRAL PARTICLES NOR VIRAL BUDDINGS WERE INDENTIFIED. HOWEVER THERE WERE TWO CHARACTERISTIC FINDINGS. AT FIRST, TUBULO-RETICULAR STRUCTURES WERE FREQUENTLY FOUND IN THE ENDOTHELIAL CELLS OF THE CAPILLARIES IN THE SUBEPITHELIAL LAYER. NEXT MULTIPLE EXTRAVASATED ERYTHROCYTES WERE ALSO OBSERVED. IN THE TISSUE SUFFRED FROM ACUTE NECROTIZING ULCERATIVE GINGIVITIS, MANY SPIROCHETAS WERE OBSERVED. THESE FINDINGS CONCERNING TWO TYPE OF PERIODONTAL DISEASE SUGGESTED THE MORPHOLOGICAL EXPRESSION IN THE GINGIVA ASSOCIATED WITH HIV-INFECTED PATIENTS.

与HIV感染密切相关的口腔病变有口腔念珠菌病、口腔毛状白斑、口内卡波西肉瘤、非霍奇金淋巴瘤和HIV相关牙周病。我们研究了被诊断为牙周炎和急性坏死性溃疡性牙龈炎的hiv感染患者的牙龈超微结构。在患牙周炎的组织中，上皮细胞水肿。病毒颗粒和病毒出芽均未被发现。然而，有两个特征的发现。首先，在上皮下层的毛细血管内皮细胞中经常发现管网状结构。其次还观察到多发红细胞外渗。急性坏死性溃疡性牙龈炎组织中可见大量螺旋体。这些关于两种牙周病的发现提示了与hiv感染患者相关的牙龈形态学表达。

项目成果

KAZUMASA SUGIHARA: "ORAL MANIFESTATIONS OF HIV-INFECTED PATIENTS-CLINICAL FEATURES AND ITS ELECTRON MICROSCOPIC FINDINGS"THE ANNALS OF KAGOSHIMA UNIVERSITY DENTAL SCHOOL. 18. 31-40 (1998)

Kazumasa Sugihara：“HIV 感染患者的口腔表现 - 临床特征及其电子显微镜检查结果”鹿儿岛大学牙科学院年鉴。

TETSURO ISHIGAMI, KAZUMASA SUGIHARA, P.A.REICHART: "ULTRASTRUCTURAL STUDY ON THE PERIODONTAL DISEASE OF HIV-INFECTED PATIENTS"JAPANESE JOURNAL OF ORAL DIAGNOSIS/ORAL MEDICINE. 12,No.1. 38-46 (1999)

TETSURO ISHIGAMI、Kazumasa SUGIHARA、P.A.REICHART：“HIV 感染者牙周病的超微结构研究”日本口腔诊断/口腔医学杂志。

KENJI HASHIMOTO: "Electron Microscopic Atlas of Oral Disease" Nagasue Shoten, 173 (1998)

桥本贤治：《口腔疾病电子显微镜图谱》长末书店，173（1998）

杉原一正: "ヒト免疫不全ウイルス感染症患者の口腔病変-臨床病態像とその電顕像について-" 鹿児島大学歯学部紀要. 18巻. 29-38 (1998)

Kazumasa Sugihara：“人类免疫缺陷病毒感染患者的口腔病变 - 临床病理特征及其电子显微镜图像”鹿儿岛大学牙科学院通报第 18 卷 29-38（1998）。

石神哲郎、杉原一正、P.A.Redhart: "HIV感染症患者の歯周疾患に関する電子顕微鏡学的研究"日本口腔診断学会雑誌. 12・1. 38-46 (1999)

Tetsuro Ishigami，Kazumasa Sugihara，P.A.：“HIV 感染患者牙周病的电子显微镜研究”日本口腔诊断学会杂志 12・1（1999 年）。