ELECTRON MICROSCOPIC STUDY ON ORAL LESIONS OF HIV-INFECTION

与HIV感染密切相关的口腔病变有口腔念珠菌病、口腔毛状白血病、口腔内Kaposi肉瘤、非何杰金淋巴瘤和HIV相关牙周病。在牙周炎的组织中，上皮细胞水肿。未发现病毒颗粒或病毒出芽。但有两个惊人的发现。首先，在上皮下层毛细血管的内皮细胞中，经常发现管状网状结构。随后还观察到多个浸提红细胞。在急性坏死性溃疡性牙龈炎的组织中，观察到许多螺旋体。这两种牙周病的形态学改变提示牙龈组织的形态学改变与HIV感染有关。

ORAL LESIONS STRONGLY ASSOCIATED WITH HIV INFECTION ARE ORAL CANDIDIASIS, ORAL HAIRY LEUKOPLAKIA, INTRAORAL KAPOSI'S SARCOMA, NON-HODGKIN LYMPHOMA AND HIV-ASSOCIATED PERIODONTAL DISEASE.WE INVESTIGATED ULTRASTRUCTURAL FINDINGS OF THE GINGIVA DIAGNOSED PERIODONTITIS AND ACUTE NECROTIZING ULCERATIVE GINGIVITIS IN HIV-INFECTED PATIENTS. IN THE TISSUE SUFFERED FROM PERIODONTITIS, EPITHELIAL CELLS WERE EDEMATOUS. NEITHER VIRAL PARTICLES NOR VIRAL BUDDINGS WERE INDENTIFIED. HOWEVER THERE WERE TWO CHARACTERISTIC FINDINGS. AT FIRST, TUBULO-RETICULAR STRUCTURES WERE FREQUENTLY FOUND IN THE ENDOTHELIAL CELLS OF THE CAPILLARIES IN THE SUBEPITHELIAL LAYER. NEXT MULTIPLE EXTRAVASATED ERYTHROCYTES WERE ALSO OBSERVED. IN THE TISSUE SUFFRED FROM ACUTE NECROTIZING ULCERATIVE GINGIVITIS, MANY SPIROCHETAS WERE OBSERVED. THESE FINDINGS CONCERNING TWO TYPE OF PERIODONTAL DISEASE SUGGESTED THE MORPHOLOGICAL EXPRESSION IN THE GINGIVA ASSOCIATED WITH HIV-INFECTED PATIENTS.