ELECTRON MICROSCOPIC STUDY ON ORAL LESIONS OF HIV-INFECTION

与HIV感染密切相关的口腔病变有口腔念珠菌病、口腔毛状白斑、口腔内Kaposi肉瘤、非霍奇金淋巴瘤和HIV相关性牙周病。在牙周炎的组织中，上皮细胞呈水肿状。病毒颗粒和病毒萌芽都没有被识别出来。然而，有两个独具特色的发现。首先，毛细血管内皮下层的内皮细胞中常可见管状网状结构。其次，还观察到多个胞外红细胞。在急性坏死性溃疡性牙周炎的组织中，可见大量的螺旋体。这些关于两种类型牙周病的研究结果表明，HIV感染患者的牙周组织中存在形态表达。

ORAL LESIONS STRONGLY ASSOCIATED WITH HIV INFECTION ARE ORAL CANDIDIASIS, ORAL HAIRY LEUKOPLAKIA, INTRAORAL KAPOSI'S SARCOMA, NON-HODGKIN LYMPHOMA AND HIV-ASSOCIATED PERIODONTAL DISEASE.WE INVESTIGATED ULTRASTRUCTURAL FINDINGS OF THE GINGIVA DIAGNOSED PERIODONTITIS AND ACUTE NECROTIZING ULCERATIVE GINGIVITIS IN HIV-INFECTED PATIENTS. IN THE TISSUE SUFFERED FROM PERIODONTITIS, EPITHELIAL CELLS WERE EDEMATOUS. NEITHER VIRAL PARTICLES NOR VIRAL BUDDINGS WERE INDENTIFIED. HOWEVER THERE WERE TWO CHARACTERISTIC FINDINGS. AT FIRST, TUBULO-RETICULAR STRUCTURES WERE FREQUENTLY FOUND IN THE ENDOTHELIAL CELLS OF THE CAPILLARIES IN THE SUBEPITHELIAL LAYER. NEXT MULTIPLE EXTRAVASATED ERYTHROCYTES WERE ALSO OBSERVED. IN THE TISSUE SUFFRED FROM ACUTE NECROTIZING ULCERATIVE GINGIVITIS, MANY SPIROCHETAS WERE OBSERVED. THESE FINDINGS CONCERNING TWO TYPE OF PERIODONTAL DISEASE SUGGESTED THE MORPHOLOGICAL EXPRESSION IN THE GINGIVA ASSOCIATED WITH HIV-INFECTED PATIENTS.