The investigations of the effects of fatty acids administration on the functions of aorta

1.长期给予二十碳五烯酸乙酯（EPA-E）改善了KKAy糖尿病小鼠主动脉中乙酰胆碱诱导的舒张反应。2.长期给予EPA-E对SNP诱导的主动脉舒张反应性没有影响。3. EPA-E的慢性给药对主动脉的收缩反应性没有影响。4.EPA-E（10 μ M）对小鼠的生长无明显影响。然而，EPA、DPA或DHA（10 μ M）在PGF 2-α 5诱导的收缩后直接诱导显著的舒张反应。总之，EPA-E给药显示出对KKAy糖尿病小鼠血管内皮细胞功能障碍的治疗效果。

1.Chronic administration of eicosapentaenoic acid ethyl ester (EPA-E) improved Ach-induced relaxation reactivity in the aorta of KKAy diabetic mice. 2.Chronic administration of EPA-E showed no effect on SNP-induced relaxation reactivity in the aorta. 3.Chronic administration of EPA-E showed no effect on the contraction reactivity in the aorta. 4.EPA-E(10microM)did not induce any effect. However, EPA, DPA or DHA(10microM) directly induced remarkable relaxation reaction after the contraction induced by PGF2-alpha.5. In conclusion, EPA-E administration showed the therapeutic effect on the functional disorder of vascular endothelial cells in KKAy diabetic mice.