Pathophysiology of non-obese subjects with impaired glucose tolerance

糖耐量受损的非肥胖受试者的病理生理学

• 批准号: 23500857
• 负责人: SATO Fumihiko
• 金额: $ 3.16万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500857/
• 关键词: 耐糖能障害; インスリン抵抗性; インスリン分泌; 異所性脂肪

The mechanisms of hyperglycemia in non-obese IGT subjects are not fully understood. In this project, to clarify the pathophysiology in non-obese IGT, we performed glucose clamp and oral glucose tolerance test with double glucose tracer. Our preliminary result suggested that impaired hepatic glucose uptake and insulin resistance in muscle may contribute to hyperglycemia in IGT subjects. Further experiment will be required for confirming these results.

非肥胖IGT受试者中高血糖的机制尚未完全了解。本研究采用葡萄糖钳夹和口服葡萄糖耐量试验，探讨非肥胖性IGT的病理生理机制。我们的初步结果表明，肝脏葡萄糖摄取受损和肌肉胰岛素抵抗可能有助于IGT患者的高血糖。需要进一步的实验来证实这些结果。

项目成果

Changes in Intramyocellular Lipid Accumulation and Insulin Sensitivity after High-Fat Loading Are Associated with Transcriptional Response in Human Skeletal Muscle.

高脂肪负荷后肌细胞内脂质积累和胰岛素敏感性的变化与人类骨骼肌的转录反应相关。

• 发表时间: 2011
• 作者: Kakehi S;Tamura Y;Sakurai Y;Takeno K;Kawaguchi M;Sato F;Ikeda S;Kim M;Yamamoto R;Ogura Y;Saga N;Katamoto S;Fujitani Y;Hirose T;Kawamori R,Watada H
• 通讯作者: Kawamori R,Watada H

Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men.

• DOI: 10.1111/j.2040-1124.2010.00091.x
• 发表时间: 2011-08-02
• 期刊: Journal of diabetes investigation
• 影响因子: 3.2
• 作者: Sakurai Y;Tamura Y;Takeno K;Kumashiro N;Sato F;Kakehi S;Ikeda S;Ogura Y;Saga N;Naito H;Katamoto S;Fujitani Y;Hirose T;Kawamori R;Watada H
• 通讯作者: Watada H

Gene expression difference of skeletal musclle between intramyocellar accumelated insulin sensitive and insulin resistant individuarls.

肌细胞内积累的胰岛素敏感和胰岛素抵抗个体骨骼肌基因表达差异。

• 发表时间: 2011
• 作者: Kawaguchi M;Tamura Y;Takeno K;Sakurai Y;Sato F;Kakehi S;Ikeda S;Kim M;Yamamoto R;Ogura Y;Saga N;Katamoto S;Kanazawa A;Fujitani Y;Hirose T;Kawamori R,Watada H
• 通讯作者: Kawamori R,Watada H

糖尿病薬物療法 BRUSHUP,

糖尿病药物治疗BRUSHUP，

• 发表时间: 2011
• 作者: Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Shimada N;Ohtsu T;Shirasawa T;Ochiai H;Hoshino H;Takashima Y;佐藤文彦
• 通讯作者: 佐藤文彦

Gene Expression Profile in Skeletal Muscle Related to the intracellular Lipid Accumulation in Endurance Athletes.

与耐力运动员细胞内脂质积累相关的骨骼肌基因表达谱。

• 发表时间: 2011
• 作者: Takeno K;Tamura Y;Sakurai Y;Sakurai Y;Sato F;Kakehi S;Ikeda S;Kim M;Yamamoto R;Ogura Y;Saga N;Katamoto S;Fujitani Y;Hirose T;Kawamori R,Watada H
• 通讯作者: Kawamori R,Watada H