Development of measurement for metabolic flexibility by oral glucose load

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Hyper-insulinemia changes metabolic situation from fat to carbohydrate. Metabolic flexibility (MF) is defined as delta RQ, reflecting metabolic switching from fat to carbohydrate, during hyper-insulinemic clamp. The aim of the present study is to establish new method to evaluate MF by oral glucose load. We demonstrated that maximum RQ determined by clamp was similar to that by oral glucose load. However, delta RQ during OGTT did not predict delta RQ during hyper-insulinemic clamp (MF).