Study on physiological function of the bivalve mainly on lipid metabolism

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We examined effects of the Freshwater Clam (Corbicula fluminea) on cholesterol metabolism. The structure of the active ingredient in the lipid fraction of the heated water extract of the Freshwater Clam (Corbicula fluminea) was a ceramide phosphoramidate molecular species.We extracted RNA from the liver of rat given the lipid fraction or the protein fraction. We performed microarray analysis using all RNA and analyzed bioinformatics. Promotion of the cholesterol catabolism and remarkable depression of activities of enzymes of fatty acid synthesis were seen in the rat given the lipid fraction. In addition, it was suggested that the lipid fraction acted on processing of the protein of SREBP. Promotion of the cholesterol catabolism was also seen in the rat given the protein fraction.