Study on physiological function of the bivalve mainly on lipid metabolism

以脂质代谢为主的双壳类生理功能研究

• 批准号: 23500931
• 负责人: MOCHIZUKI Satoshi
• 金额: $ 3.24万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500931/
• 关键词: タイワンシジミ; コレステロール代謝; 脂質画分; タンパク質画分; マイクロアレイ; 遺伝子発現; 構造決定; セラミド; コレステロール

We examined effects of the Freshwater Clam (Corbicula fluminea) on cholesterol metabolism. The structure of the active ingredient in the lipid fraction of the heated water extract of the Freshwater Clam (Corbicula fluminea) was a ceramide phosphoramidate molecular species.We extracted RNA from the liver of rat given the lipid fraction or the protein fraction. We performed microarray analysis using all RNA and analyzed bioinformatics. Promotion of the cholesterol catabolism and remarkable depression of activities of enzymes of fatty acid synthesis were seen in the rat given the lipid fraction. In addition, it was suggested that the lipid fraction acted on processing of the protein of SREBP. Promotion of the cholesterol catabolism was also seen in the rat given the protein fraction.

我们研究了淡水蛤（Corbicula fluminea）对胆固醇代谢的影响。 从河蚬（Corbicula fluminea）的热水提取物的脂质部分中提取的活性成分的结构是神经酰胺磷酸酯分子种类。我们使用所有RNA进行微阵列分析并进行生物信息学分析。在给予脂质组分的大鼠中观察到胆固醇催化活性的促进和脂肪酸合成酶活性的显著抑制。 此外，还表明脂质组分对SREBP蛋白质的加工有一定的作用。 在给予蛋白质组分的大鼠中也观察到胆固醇催化剂的促进作用。

项目成果

Freshwater Clam Extract Ameliorates Triglyceride and Cholesterol Metabolism through the Expression of Genes Involved in Hepatic Lipogenesis and Cholesterol Degradation in Rats.

• DOI: 10.1155/2013/830684
• 发表时间: 2013
• 期刊: Evidence-based complementary and alternative medicine : eCAM
• 作者: Laurent T;Okuda Y;Chijimatsu T;Umeki M;Kobayashi S;Kataoka Y;Tatsuguchi I;Mochizuki S;Oda H
• 通讯作者: Oda H

研究業績を公表(ホームページ等)

研究成果的发表（主页等）

二枚貝、特にシジミの機能性因子に関する研究

双壳类特别是蚬类软体动物功能因子的研究

• 发表时间: 2013
• 期刊: New Food Industry
• 作者: 千々松武司;山田耕史;小田裕昭;望月 聡
• 通讯作者: 望月 聡

Lipid components prepared from a freshwater Clam (Corbicula fluminea) extract ameliorate in hypercholesterolaema in rats fed high-cholesterol diet.

从淡水蛤（Corbicula Fluminea）提取物中提取的脂质成分可改善高胆固醇饮食大鼠的高胆固醇血症。

• 发表时间: 2013
• 期刊: Food Chem.
• 作者: T.Chijimatsu;M.Umeki;Y.Kataoka;S.Kobayashi;K.Yamada;H.Oda;and S.Mochizuki
• 通讯作者: and S.Mochizuki

Lipid components prepared from a freshwater Clam (Corbicula fluminea) extract ameliorate in hypercholesterolaema in rats fed high-cholesterol diet

由淡水蛤（Corbicula Fluminea）提取物制备的脂质成分可改善高胆固醇饮食大鼠的高胆固醇血症

• 发表时间: 2013
• 期刊: Food Chem
• 影响因子: 8.8
• 作者: T. Chijimatsu;M. Umeki;Y. Kataoka;S. Kobayashi;K. Yamada;H. Oda;and S. Mochizuki
• 通讯作者: and S. Mochizuki