Design and applications of aliphatic selenium compounds having antioxidant catalytic functions

有机硒化合物在有机合成中有着广泛的应用。然而，在硒原子和苯环之间不具有直接化学键的脂肪族硒化合物通常是不稳定的，因此尚未被广泛研究。在本研究中，我们成功地应用糖状环状或氨基酸骨架合成了稳定的脂肪族硒化合物。此外，它被证明，合成的化合物可用作酶模型，抗氧化剂，不对称催化剂，和蛋白质的折叠试剂在各种研究领域，如化学，药物化学和生物化学。

Organoselenium compounds have been widely utilized as useful reagents in the field of organic synthesis. However, aliphatic selenium compounds, which do not have a direct chemical bond between the selenium atom and a benzene ring, are generally unstable and hence have not yet been studied extensively. In this study, we succeeded in the synthesis of stable aliphatic selenium compounds by applying a sugar-like cyclic or amino acid skeleton. Moreover, it was demonstrated that the synthesized compounds are usable as enzymatic models, antioxidants, asymmetric catalysts, and folding reagents of proteins in various research fields, such as chemistry, medicinal chemistry, and biochemistry.