Regulation of cell morphology by tricellular junction in epithelia

当将每个上皮细胞的表面视图与多边形进行比较时，其侧面对应于细胞间连接，而其顶点对应于三细胞接触，其在上皮细胞形态发生中的作用尚未得到很好的研究。我们已经证明，定位于三细胞接触处的三胞蛋白通过Cdc42和Tuba调节f -肌动蛋白的组织；a Cdc42 GEF。这些发现表明，三细胞接触在肌动球蛋白介导的根尖连接复合体张力调节中起着至关重要的作用。

When the surface view of each epithelial cell is compared with a polygon, its sides correspond to cell–cell junctions, while its vertices correspond to tricellular contacts, whose roles in epithelial cell morphogenesis have not been well studied. We have shown that tricellulin, which is localized at tricellular contacts, regulates F-actin organization via Cdc42 and Tuba; a Cdc42 GEF. These findings indicate that tricellular contacts play crucial roles in regulating the actomyosin-mediated apical junctional complex tension through the tricellulin-Tuba-Cdc42 system.